The vestibulo-ocular reflex (VOR) adaptation is an ideal model for investigating how the neurosteroid 17 beta-estradiol (E2) contributes to the modification of behavior by regulating synaptic activities. We hypothesized that E2 impacts VOR adaptation by affecting cerebellar synaptic plasticity at the parallel fiber–Purkinje cell (PF) synapse. To verify this hypothesis, we investigated the acute effect of blocking E2 synthesis on gain increases and decreases in adaptation of the VOR in male rats using an oral dose (2.5 mg/kg) of the aromatase (...) inhibitor letrozole. We also assessed the effect of letrozole on synaptic plasticity at the PF synapse in vitro, using cerebellar slices from male rats. We found that letrozole acutely impaired both gain increases and decreases adaptation of the VOR without altering basal ocular-motor performance. Moreover, letrozole prevented long-term potentiation at the PF synapse (PF-LTP) without affecting long-term depression (PF-LTD). Thus, in male rats neurosteroid E2 has a relevant impact on VOR adaptation and affects exclusively PF-LTP. These findings suggest that E2 might regulate changes in VOR adaptation by acting locally on cerebellar and extra-cerebellar synaptic plasticity sites. (shrink)

Neurosteroid 17 beta-estradiol (E2) is a steroid synthesized de novo in the nervous system that might influence neuronal activity and behavior. Nevertheless, the impact of E2 on the functioning of those neural systems in which it is slightly synthesized is less questioned. The vestibulo-ocular reflex (VOR) adaptation, may provide an ideal arena for investigating this issue. Indeed, E2 modulates cerebellar parallel fiber-Purkinje cell synaptic plasticity that underlies encoding of VOR adaptation. Moreover, aromatase expression in the cerebellum of adult rodents is (...) maintained at very low levels and localized to Purkinje cells. The significance of age-related maintenance of low levels of aromatase expression in the cerebellum on behavior, however, has yet to be explored. Our aim in this study was to determine whether E2 synthesis exerts an effective and persistent modulation of VOR adaptation in adult male rats. To answer this question, we investigated the acute effect of blocking E2 synthesis on gain increases and decreases in VOR adaptation using an oral dose (2.5 mg/kg) of the aromatase inhibitor Letrozole in peri-pubertal and post-pubertal male rats. We found that Letrozole acutely impaired gain increases and decreases in VOR adaptation without altering basal ocular-motor performance and that these effects were similar in peri-pubertal and post-pubertal rats. Thus, in adult male rats neurosteroid E2 effectively modulates VOR adaptation in both of the periods studied. These findings imply that the adult cerebellum uses E2 synthesis for modulating motor memory formation and suggest that low and extremely localized E2 production may play a role in adaptive phenomena. (shrink)

The Morris water maze has been put forward in the philosophy of neuroscience as an example of an experimental arrangement that may be used to delineate the cognitive faculty of spatial memory (e.g., Craver and Darden, Theory and method in the neurosciences, University of Pittsburgh Press, Pittsburgh, 2001; Craver, Explaining the brain: Mechanisms and the mosaic unity of neuroscience, Oxford University Press, Oxford, 2007). However, in the experimental and review literature on the water maze throughout the history of its use, (...) we encounter numerous responses to the question of “what” phenomenon it circumscribes ranging from cognitive functions (e.g., “spatial learning”, “spatial navigation”), to representational changes (e.g., “cognitive map formation”) to terms that appear to refer exclusively to observable changes in behavior (e.g., “water maze performance”). To date philosophical analyses of the water maze have not been directed at sorting out what phenomenon the device delineates nor the sources of the different answers to the question of what. I undertake both of these tasks in this paper. I begin with an analysis of Morris’s first published research study using the water maze and demonstrate that he emerged from it with an experimental learning paradigm that at best circumscribed a discrete set of observable changes in behavior. However, it delineated neither a discrete set of representational changes nor a discrete cognitive function. I cite this in combination with a reductionist-oriented research agenda in cellular and molecular neurobiology dating back to the 1980s as two sources of the lack of consistency across the history of the experimental and review literature as to what is under study in the water maze. (shrink)

RESUMO: O sentimento religioso corresponde à experiência do sujeito em suas buscas por uma amorosa realização consigo mesmo, com os outros, com a natureza e com o mistério divino. Ao pensarmos no sentido formativo desse humano, interfaces da religiosidade, da psicologia e da pedagogia nos remetem aos deleites e conflitos presentes no desenvolvimento intrapessoal e relacional. Diante desse desafio, o presente artigo se propõe a refletir sobre o humano e sua formação interdisciplinar em busca de competências e habilidades para gestão (...) de conflitos interpessoais. A pesquisa, qualitativa e bibliográfica, tem bases conceituais em: Edith Stein (2002, 2003, 2004, 2005, 2007); Piaget (1977, 1994); Lévinas (2010); La Taille (1999, 2009); entre outros. Conclui-se que educação e religiosidade, em interdisciplinaridade com a Psicologia e com a Pedagogia, podem se unir no desafiador processo de resolver conflitos interpessoais. (shrink)

BackgroundLow-stakes crimes related to alcohol and/or drugs are common around the world, but research is lacking on police–suspect interactions of such crimes. A large proportion of these suspects are intoxicated during interrogations, and many may have substance use disorder, making them potentially vulnerable to interrogative pressure.MethodsTo address this lack of knowledge, the taxonomy of interrogation methods framework and a common classification of question types were applied in the coding of written police interrogations. Two archival studies, one pilot and one main (...) study analyzed police interrogations with suspects of alcohol- and drug-related crimes in Sweden.ResultsFor both Study 1 and 2, suspects showed signs of alcohol and/or drug intoxication, hangover or withdrawal in more than 50% of all interrogations. In Study 2, additional coding indicated that suspects displayed signs of substance use disorder in 57% of the interrogations. The main results from both studies revealed a large number of direct questions asked by the police across all interrogations, and relatively little use of the strategic interrogation techniques from the taxonomy of interrogation methods framework. In fact, when it came to interrogation techniques, law enforcement used more confrontational techniques in their interactions with intoxicated suspects compared to sober suspects. Furthermore, suspects displaying signs of substance use disorder were significantly more cooperative and prone to confess than suspects without indicators of substance use disorder.ConclusionAs the first novel study on low-stakes crime interrogations related to alcohol and/or drugs, the present study provides useful information about current Swedish interrogation practices and areas for improvement. The study results indicate that suspects displaying signs of intoxication or substance use disorder may be more vulnerable during police interrogations. This may in turn have the potential to inform the development of new interrogation policies. Due to the novelty of this research, more studies are needed, both on a national and international level, to examine interrogations in low-stakes crimes further. (shrink)

Efforts by governments, firms, and patients to deliver pioneering drugs for critical health needs face a challenge of diminishing efficiency in developing those medicines. While multi-sectoral collaborations involving firms, researchers, patients, and policymakers are widely recognized as crucial for countering this decline, existing incentives to engage in drug development predominantly target drug manufacturers and thereby do little to stimulate collaborative innovation. In this mini review, we consider the unexplored potential within pharmaceutical regulations to create novel incentives to encourage a diverse (...) set of actors from the public and private spheres to engage in the kind of collaborative knowledge exchange requisite for fostering enhanced innovation in early drug development. (shrink)

We present an axiomatic approach for a class of finite, extensive form games of perfect information that makes use of notions like “rationality at a node” and “knowledge at a node.” We distinguish between the game theorist's and the players' own “theory of the game.” The latter is a theory that is sufficient for each player to infer a certain sequence of moves, whereas the former is intended as a justification of such a sequence of moves. While in general the (...) game theorist's theory of the game is not and need not be axiomatized, the players' theory must be an axiomatic one, since we model players as analogous to automatic theorem provers that play the game by inferring (or computing) a sequence of moves. We provide the players with an axiomatic theory sufficient to infer a solution for the game (in our case, the backwards induction equilibrium), and prove its consistency. We then inquire what happens when the theory of the game is augmented with information that a move outside the inferred solution has occurred. We show that a theory that is sufficient for the players to infer a solution and still remains consistent in the face of deviations must be modular. By this we mean that players have distributed knowledge of it. Finally, we show that whenever the theory of the game is group-knowledge (or common knowledge) among the players (i.e., it is the same at each node), a deviation from the solution gives rise to inconsistencies and therefore forces a revision of the theory at later nodes. On the contrary, whenever a theory of the game is modular, a deviation from equilibrium play does not induce a revision of the theory. (shrink)

Previous research investigating handle-response compatibility effects with graspable objects used different categories of objects as stimuli, regardless of their specific, intrinsic characteristics. The current study explores whether different types of objects’ characteristics may elicit different types of spatial compatibility, that is, handle-response and response-effect compatibility as well as their potential interaction. In Experiment 1, objects having a graspable handle opposite to either a visible functional component (i.e.,handle-function objects: a teapot) or a latent functional component (handle-only objects: a pitcher lacking the (...) spout) were presented separately in different blocks. Both the handle and the goal-directed functional components of these objects were located on the horizontal axis. In Experiment 2, handle-only objects had a handle located on the horizontal axis and a latent functional component located on the vertical axis (e.g., a cup). In both experiments, participants were required to judge the material (plastic and metal) the object was made of. Results showed that the handle-response compatibility effect was sensitive to whether the actions consequences of object manipulation took place on the horizontal rather than on the vertical axis. (shrink)

L’introduzione al fascicolo Analogia e medioevo sive vent’anni di analogie presenta il numero 18 di "Doctor Virtualis" e traccia le tappe fondamentali della rivista. Si delineano dapprima alcune linee della storia della rivista e le sue ispirazioni teoriche e storiografiche principali, per poi mettere in luce le ragioni della rilevanza del tema dell’analogia, come oggetto utilizzato e pensato nei secoli medievali e come strumento di ricerca storiografica, e infine si conclude con l’articolazione del fascicolo. The introduction to the issue Analogy (...) and the Middle Ages sive twenty years of analogies presents issue n. 18 of Doctor Virtualis and traces the milestones of the journal. It first sketches some lines of the history of the journal and its main theoretical and historiographical inspirations, then highlights the reasons for the relevance of the theme of analogy, as an object used and thought of in the medieval centuries and as a tool for historiographical research, and finally concludes with the articulation of the issue. (shrink)

Considerando a importância das Habilidades Sociais no desenvolvimento acadêmico e profissional dos estudantes, esta pesquisa tem por objetivo verificar a existência de relações entre Habilidades Sociais e desempenho acadêmico. Este estudo caracteriza-se por uma pesquisa descritiva correlacional quantitativa, na qual participaram 628 estudantes universitários das áreas de saúde e humanas e exatas e sociais aplicadas que responderam ao Inventário de Habilidades Sociais – IHS (Del Prette & Del Prette, 2014). Para o tratamento dos dados, foi utilizado o Statistical Package for (...) the Social Sciences (IBM SPSS) 21.0 para Windows, valendo-se de testes correlacionais. Foi possível verificar a correlação entre Habilidades Sociais e desempenho acadêmico nos cursos de saúde e humanas, em contrapartida, não há correlação estatisticamente significativa entre ambos nos cursos das áreas de exatas e sociais aplicadas. Encontra-se respaldo teórico nestas verificações, sendo possível analisá-las neste artigo. (shrink)

BackgroundThe psychological burden possibly deriving from not immediately undergoing radical treatment for prostate cancer could be a potential disadvantage of active surveillance, especially in the eve of some relevant clinical exams [i.e., re-biopsy, prostate-specific antigen test, and medical examination]. Even if it is known from the literature that the majority of PCa men in AS do not report heightened anxiety, there is a minority of patients who show clinically significant levels of anxiety after diagnosis. The present study aimed to investigate (...) if demographic, clinical, and psychological variables at the entrance in AS were associated with the risk of developing clinically significant PCa-related anxiety 2 months before the first re-biopsy and to offer psychological support to improve quality of life.Materials and MethodsA total of 236 patients participated in the PCa Research International: AS protocol and in PRIAS-QoL study. Demographic/clinical features, health-related QoL domains, coping with cancer, PCa-related anxiety [Memorial Anxiety Scale for PCa ], personality traits, and decision-making-related factors were assessed at T0. MAX-PC was also administered at T1. PCa-related anxiety at T1 was considered to be of clinical significance if the MAX-PC score was ≥1.5. Multivariable logistic regression coupled to bootstrap was used to detect factors associated with high levels of anxiety.ResultsThe median age was 64.4 years. Fifty-six patients reported MAX-PC total score above the cutoff. Three factors were associated with a high level of PCa anxiety at T1: anxious preoccupation [odds ratio = 4.36], extraversion, and prostate-related symptoms. Physical well-being was associated with a low PCa anxiety subscale ; neuroticism and functional well-being were associated with PSA anxiety. Neuroticism and helplessness/hopelessness were associated with fear of progression.ConclusionOnly a partial portion of the sample experienced significant levels of anxiety after 10 months. Psychological assessment should be routinely conducted to detect risk factors for increased anxiety, offering tailored psychological interventions aimed at promoting interpersonal awareness and emotional well-being. (shrink)

The difficulties of the biological taxonomy development are argued to have been historically associated with two main problems: 1) the problem of searching for essential features which was unachievable within the framework of empiric taxonomy andcould be solved as a part of the mature theory; 2) the problem of developing of a model of the biological object the remedies of which were developed only in the XX century. The author argues that both problems are associated with the development of classificatory (...) and system ontology and the relevant methodologies. The classificatory methodology from its inception is argued to have developed as a means of classification of biological diversity; furthermore it is claimed to have been assumed that the features representing classes possessed ontological nature that is they actually represent individual objects. The author concludes that taking into account the empiric nature of taxonomy that assumption turned to be false. In the modern taxonomy along with the classical approach a classificatory-system approach was developed. Fundamentally, it is a transition from the classical approach to the modern one which is held to imply the development of a system model of the study subject. (shrink)

The author investigates the content of the notion of subject from the evolutionary-epistemological point of view. She claims that evolutionary epistemology does not clarify this problem by itself and argues that this state of affairs raises a number of problems such as absolutization of adaptationism, biologism in knowledge, lack of a clear demarcation between animal cognition and human cognitive activity. It is argued that a man is the only subject of cognition in evolutionary epistemology. Inasmuch as person constructs and enriches (...) the environment he becomes a pressure factor by himself. This claim is argued to counter the thesis of adaptation. So adaptationist interpretation of the evolution of human cognitive activity is insufficient. The phenomenon of environmental change through the development of cognitive abilities by the person is represented in society, communication and culture. Cognition is determined by anticipating the result of purpose. In this connection, the constructive activity of the cognitive person confronted with the limitations of her own cognitive capabilities and environmental restricting factors. Thus, the evolution of man is considered as self-development, which is carried out through the creative overcoming external and internal constraints through the constructive activity of the agent of cognition. (shrink)

The study of Kant’s anthropology, proposed by Viktor Kozlovskyi in its original and thorough monograph, is an entirely new interpretation of Kant’s answer to the fundamental question “What is man?”. On the basis of the philosopher’s heritage and taking into account the large body of research lit-erature, Kozlovskyi reconstructs five conceptual “human models” in Kant’s anthropological discourse. However, this study contains a number of problematic statements and conclusions. I argue first, that there is some inconsistency between Kant’s understanding of the (...) concept of “anthropology” and Ko-zlovskyi’s explanation. Second, the model of man as intelligible being, made explicit through the con-cepts of “freedom” and “spontaneity”, is a justified construction within the limits of criticism, but not quite correct with regard to the place and function of “anthropology” in it. Third, we can see a disso-nance between Kozlovskyi’s explanation of the constellations as “chronotopes-events” and interpreta-tion of this concept by Dieter Henrich’s school, where the methodology of “research constellations” was used to elucidate the early phase of German idealism. However, this leads to the cardinal question of how far this methodology is applicable for the analysis of Kant’s philosophy. (shrink)

Sandel's book argues against genetic enhancement as an illegitimate expression of a drive to human mastery and a rejection of the proper appreciation of the gift of life. His view combines bad theology with bad virtue ethics, and exemplifies the problem of status quo bias in ethics.

Em diversos momentos de sua trajetória filosófica Deleuze recorre à Leibniz. Num primeiro momento para pensar a síntese ideal da diferença em Diferença e Repetição, não sem antes ter tecido duras críticas ao infinito leibniziano. Neste artigo nos consagraremos a este momento. Buscaremos demonstrar a importância do conceito de causa imanente de Espinosa, assim como do princípio de razão suficiente e de suas funções no pensamento leibniziano. Apresentaremos a crítica deleuziana do conceito de identidade em Leibniz e a interpretação do (...) cálculo diferencial que serve de base para a construção do processo de determinação conceitual, ou seja, para a síntese ideal da diferença, tema do capítulo IV de Diferença e repetição. A relevância deste artigo está na tentativa de demonstrar que a tese da univocidade do ser não pode ser compreendida sem sua contrapartida, a equivocidade dos sentidos através dos quais o ser se diz e em explorar consequências desta tese para a reconstrução deleuziana da relação empírico-transcendental. Procuraremos demonstrar que Deleuze precisa recorrer a Leibniz para pensar a diferença ilimitada. (shrink)

Descartes maintains that we can love God and that it is pleasant and morally beneficial to do so. In this essay, I examine the necessary conditions for such an intellectual love of God. I argue that the intellectual love of God is incited by a judgment that we are joined to God in reality, which is constitutive of an intellectual joy. I go on to show that the intellectual love of God is, itself, constituted by a stripping of our private (...) interests in favor of God’s divine will. (shrink)

The precarious rights of senior citizens, especially those who are highly educated and who are expected to counsel and guide the younger generations, has stimulated the creation internationally of advocacy associations and opinion leader groups. The strength of these groups, however, varies from country to country. In some countries, they are supported and are the focus of intense interest; in others, they are practically ignored. For this is reason we believe that the creation of a network of all these associations (...) is essential. The proposed network would act as a support for the already-existing policies of the United Nations’ High Commission for Human Rights, of independent experts, and of the Global Alliance for the Rights of Older People. All three have long ago recommended the creation of a recognized instrument for uniting presently scattered efforts. The proposed network, therefore, will seek to promote the international exchange of relevant expertise, and it will reinforce the commitments and actions that single countries are currently taking to meet these objectives. For example, informative public events can be organised to promote particular support initiatives and to provide an opportunity for new members of the network to be presented. The network will promote health for senior citizens, disease prevention, senior mobility, safe free time for seniors, alimentary education, protection against new risks and dangers, as well as equity in the services necessary for seniors to adopt new information and communication technologies. In the case of retired academic members, the network will promote equality with respect to continuing use of digital technologies (particularly email), continuing access to research libraries, and the guaranteed ability for seniors to fund their own research programs and to deliver free seminars. (shrink)

Informed consent is an essential step in helping patients be aware of consequences of their treatment decisions. With surgery, it is vitally important for patients to understand the risks and benefits of the procedure and decide accordingly. We explored whether a written IC form was provided to patients; whether they read and signed it; whether they communicated orally with the physician; whether these communications influenced patient decisions. Adult postsurgical patients in nine general hospitals of Italy’s Campania Region were interviewed via (...) a structured questionnaire between the second and seventh day after the surgery at the end of the first surgical follow up visit. Physicians who were independent from the surgical team administered the questionnaire. The written IC form was given to 84.5% of those interviewed. All recipients of the form signed it, either personally or through a delegate; however, 13.9% did not know/remember having done so; 51.8% said that they read it thoroughly. Of those who reported to have read it, 90.9% judged it to be clear. Of those receiving the written consent form, 52.0% had gotten it the day before the surgery at the earliest 41.1% received it some hours or immediately before the procedure. The written IC form was explained to 65.6% of the patients, and 93.9% of them received further oral information that deemed understandable. Most attention was given to the diagnosis and the type of surgical procedure, which was communicated respectively to 92.8 and 88.2% of the patients. Almost one in two patients believed that the information provided some emotional relief, while 23.2% experienced increased anxiety. Younger patients and patients with higher levels of education were more likely to read the written IC form. The written IC form is not sufficient in assuring patients and making them fully aware of choices they made for their health; pre-operative information that was delivered orally better served the patients’ needs. To improve the quality of communication we suggest enhancing physicians’ communication skills and for them to use structured conversation to ensure that individuals are completely informed before undergoing their procedures. (shrink)

The distinction between “empathy” and “sympathy” in the context of ethics is a dynamic and challenging one. The eighteenth century texts of David Hume and Adam Smith used the word "sympathy," but not "empathy," although the conceptual distinction marked by empathy was doing essential work in their writings. After discussing the early uses of these terms, this article is organized historically. Two traditions are distinguished. The first is the Anglo-American tradition, and it extends from Hume and Smith to the twenty-first (...) century work of Michael Slote. Stephen Darwall’s contribution is applied in engaging Hume and Smith. Finally, the interrelation of empathy, sympathy and altruism is explored in the work of John Rawls and Thomas Nagel. The second tradition is the Continental one. It extends from the spirituality of Johann Herder to the phenomenological movement of Edmund Husserl, Martin Heidegger, Max Scheler, and Edith Stein. The intentional analysis of empathy is directly relevant to the constitution of the social community in a broad, normative relationship with the "Other.". (shrink)

Recent work by Keyser in applied epistemology of experiment has focused on the iterative ‘production’ of knowledge: knowledge stabilizes within a given physical context and it is iteratively tested within that context to meet standards of reliability. This implies that in a given physical context (e.g., laboratory), the inferences, methods/techniques, and physical products form coherence relations with one another. We apply this epistemological stabilization account to the martial arts in order to argue that the context of stabilization dictates the training (...) methods, techniques, and even the philosophical concepts of a given martial arts system. We describe key elements of stabilization pertaining to rules, training methodology, warrior philosophy, and spectator/media tropes. The account of stabilization requires a case study that shows how a dynamic system is stabilized. We describe the stabilization of modern mixed martial arts by tracking it on a time scale, but also in different contexts (e.g., Pancrase, Pride, UFC). (shrink)

The implicit activities of the living body in sports (such as heart rate, involuntary gestures, stress, reflex, emotional regulation and interaction expressions) emerge in the consciousness of the lived body without our voluntary control. We demonstrate physiological emersion, and how, including in dramaturgical perception, physiological flows and processes collide with the image of a whole body. In this paper, we introduce corporeal non-property as the missing (?) link between phenomenology and neuroscience, renewed by research on the cerebral unconscious and the (...) perception of their lived body. Rather than mindfulness, physical activity obliges the subject to learn the unconscious and his motor skills from his living body: a new psychoanalysis of sport is thus established by studying what emerges from the activity of the living body up to the level of the conscious description of motor action. In this paper, we explain why that awareness occurs, and why it matters for the understanding of unconscious activity of the athlete’s living body. This is potentially interesting, although it needs, as a theory, to overcome the obvious reliance of the body on unconscious or habitual/automated physiological processes. But the incorporation of body techniques forms a habitus. (shrink)

We defend in this essay Paul Ricœur’s hermeneutics of suspicion against Toril Moi’s debunking of it as a misguided interpretation of the practice of critical inquiry, and we relate the practice of a rigorous and critical empathy to the hermeneutics of suspicion. For Ricœur, empathy would not be a mere psychological mechanism by which one subject transiently identifies with another, but the ontological presence of the self with the Other as a way of being —listening as a human action that (...) is a fundamental way of being with the Other in which “hermeneutics can stand on the authority of the resources of past ontologies.” In a rational reconstruction of what a Ricœur-friendly approach to empathy would entail, a logical space can be made for empathy to avoid the epistemological paradoxes of Husserl and the ethical enthusiasms of Levinas. How this reconstruction of empathy would apply to empathic understanding, empathic responsiveness, empathic interpretation, and empathic receptivity is elaborated from a Ricœurian perspective. (shrink)

When Kepler concluded that the orbit of Mars was not a circle, he was led to the belief that the orbit was an oval touching the circle at the apsides and lying within the circle at other points. In the definition of the oval, physical hypotheses played a primary role. Two forces were involved; a tractive force arising from the effect of the solar rays rotating with the sun, and a directing force arising from a natural instinct of the planet (...) itself. The former pushed the planet along the orbit while the latter enabled the planet to steer itself across the stream of the solar vortex in a small epicycle. In adopting this physical theory to determine the oval, Kepler was led into what he himself described as ‘a new labyrinth’. After several attempts to construct the oval, and by progressively eliminating the sources of error from his calculating procedures in order to arrive at an accurate mathematical formulation of the physical hypotheses, he was able to conclude that the oval was inconsistent with the empirical data and the physical theory in need of modification. (shrink)

Protagoras’ declaration that “man is the measure of all things” is conventionally discussed in the context of epistemology. There was, however, a communal or social dimension to this even in ancient Greece. In the unfolding process of time, this latter dimension assumed greater intensity and expanded systematically into all aspects of human relations. The centrality of money in these relations speaks to the transition from “man is the measure of all things” to money is the measure of all things. It (...) is precisely this thesis that the present essay proposes to defend. (shrink)

This little volume shows a remarkable familiarity with both continental and Anglo-American literature on the subjects of probability and induction. Discussion is both expository and critical. The author argues in favor of a psychological-pragmatic interpretation of the principle of induction and the theory of confirmation.--A. P. D. M.

_Diversity and Community: An Interdisciplinary Reader_ is a collection of essays exploring the notion of community in its many theoretical, practical, and cultural manifestations. A collection of specially commissioned essays exploring the notion of community in its many theoretical, practical, and cultural manifestations. Discusses the idea of community in its full, cultural context. Deals with issues confronting many diverse groups, including African American, Franco-Canadian, computer-mediated, and gay and lesbian communities. Includes contributions by both eminent schlars and new voices, among them (...) Martha Nussbaum, Jean Bethke Elsthain, D.A. Masolo, Mary Hawkesworth, Lewis Gordon, Maria Lugones, Crispin Sartwell, Duane Champagne, and Frank Cunningham. (shrink)

Background: The importance of trust between patients and healthcare personnel is emphasised in nurses’ and physicians’ ethical codes. Trust is crucial for an effective healthcare personnel–patient relationship and thus for treatment and treatment outcomes. Cultural and linguistic differences may make building a trusting and positive relationship with ethnic minority patients particularly challenging. Although there is a great deal of research on cultural competence, there is a conspicuous lack of focus on the concepts of trust and distrust concerning ethnic minority patients, (...) particularly in relation to the concept of ‘othering’. Aim: To study which factors help build trust or create distrust in encounters between healthcare professionals and hospitalised ethnic minority patients, as well as study the dynamic complexities inherent within the process of ‘othering’. Research design: Qualitative design, in-depth interviews and hermeneutic analysis. Participants and research context: The interviewees were 10 immigrant patients (six women and four men – eight Asians, two Africans – ages 32–85 years) recruited from a south-eastern Norwegian hospital. Ethical considerations: Study approval was obtained from the hospital’s Privacy Ombudsman for Research and the hospital’s leadership. Participation was voluntary and participants signed an informed consent form. Conclusion: Distrust and othering may be caused by differences in belief systems, values, perceptions, expectations, and style of expression and behaviour. Othering is a reciprocal phenomenon in minority ethnic patient–healthcare personnel encounters, and it influences trust building negatively. Besides demonstrating general professional skill and competence, healthcare personnel require cultural competence to create trust. (shrink)

Shortages in the number of donated organs after death and the growing number of end-stage organ failure patients on waiting lists call for looking at alternatives to increase the number of organs that could be used for transplantation purposes. One option that has led to a legal and ethical debate is to have regulated markets in human organs. Opponents of a market in human organs offer different arguments that are mostly founded on contingent factors that can be adjusted. However, some (...) authors have asked the question whether we still have a reason to believe that there is something wrong with offering human organs for sale for transplantation purposes, even if the circumstances under which the practice takes place are improved. One prominent argument regarding this appeals to the notion of human dignity. It is argued that organ selling violates human dignity. This paper presents a systematic discussion of dignity-based arguments in the organ selling debate, and then develops a social account of dignity. It is argued that allowing the practice of organ selling inherently runs the risk of promoting the notion that some persons have less worth than others and that persons have a price, which is incompatible with dignity. The approach is defended against possible objections and it is shown that it can capture the notion that autonomy is linked to human dignity in important ways, while dignity at the same time can constrain the autonomous choices of persons with regards to certain practices. (shrink)

As a consequence of the problems caused by genetic discrimination, federal and state law makers are being pressured to pass a legislative remedy. A primary question is whether the Americans with Disabilities Act of 1990 applies to individuals with a potentially disabling genetic disorder who are pre-symptomatic or asymptomatic and may never become ill and to healthy individuals who are carriers of genetic conditions. At present, this question has relevance principally for individuals with the genotype for single gene disorders, like (...) Huntington disease and hemochromatosis, and to asymptomatic carriers of single gene disorders such as cystic fibrosis. Although many such single gene conditions exist, the total incidence of these conditions in the U.S. population is less than 0.4 percent. However, the question concerning the applicability of the ADA will become increasingly important because genetic tests will almost certainly be developed in the near future for common multifactorial diseases like diabetes, heart disease, and certain forms of cancer. (shrink)

In order to consider how best to address relationship concerns with potential research participants arising in this study, we will first describe unique features...

Institutions are naturally seen as the stable and relatively fixed backbone of the social world. While the structural role of institutions is usually discussed in social ontology, the temporal implications of this regulation are often overlooked. It is indeed tempting to take a present-centred approach to institutions. The latter clearly are instrumental in stabilizing and structuring the social coordination between a number of actors. But it is all too easy to focus only on their role in syn...

The purpose of this paper is to consider the following three problems:(1) Whether selective conscientious objection is morally reasonable in general; and if so,(2) Whether selective conscientious objection should be recognized as a constitutional right by judicial interpretation; or(3) Whether selective conscientious objection should become part of any new draft law that would be passed by Congress.

The article discusses the theoretical and analytical relevance of spontaneity, the basis of creativity, considered as a central aspect of the semiotic model of C. S. Peirce, through the study of its incidence on human identity, on the self. To do so, I work with a series of technical concepts ..

We prove a consistency result about square principles and stationary reflection which generalises the result of Ben-David and Magidor [4].

Intermediate constructs are required as bridges between complex behaviors and realistic models of neural circuitry. For cognitive scientists in general, schemas are the appropriate functional units; brain theorists can work with neural layers as units intermediate between structures subserving schemas and small neural circuits.After an account of different levels of analysis, we describe visuomotor coordination in terms of perceptual schemas and motor schemas. The interest of schemas to cognitive science in general is illustrated with the example of perceptual schemas in (...) high-level vision and motor schemas in the control of dextrous hands.Rana computatrix, the computational frog, is introduced to show how one constructs an evolving set of model families to mediate flexible cooperation between theory and experiment. Rana computatrix may be able to do for the study of the organizational principles of neural circuitry what Aplysia has done for the study of subcellular mechanisms of learning. Approach, avoidance, and detour behavior in frogs and toads are analyzed in terms of interacting schemas. Facilitation and prey recognition are implemented as tectal-pretectal interactions, with the tectum modeled by an array of tectal columns. We show how layered neural computation enters into models of stereopsis and how depth schemas may involve the interaction of accommodation and binocular cues in anurans. (shrink)